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Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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The average size of the lesions was 3. The etiology and pathogenesis of LMDF are unknown. Please review our privacy policy. Typical skin lesions of LMDF are diwseminatus discrete, smooth, mm, monomorphic, symmetrical reddish-brown or brown-to-yellowish dome-shaped translucent papules and nodules occurring on the chin, forehead, cheeks, and eyelids.

The only treatment-related adverse effects were treatment-site erythema and edema that lasted 1 to 2 days.

Lupus miliaris disseminatus faciei pathology | DermNet NZ

Microscopic findings are essential for diagnosis and characteristically reveal superficial granulomatous inflammation surrounding caseation necrosis that is often perifollicular in distribution, although LMDF is now regarded as a spectrum classified into three histological stages: DermNet NZ does not provide an online consultation service.

Open in a separate window. A distinctive rosacea-like syndrome and not a granulomatous form of rosacea. The clinical presentation of LMDF has classically been described as multiple, smooth, mm brown-red, brown, to yellowish dome-shaped papules to nodules distributed symmetrically on the central and lateral face and around the eyelids, more often involving the lower eyelids [ 1 – 5 ].


Diascopy of larger lesions often reveals an apple-jelly nodule-like appearance. There was no accompanying scaling, telangiectasia, or flushing.

It is considered by some to be part of a spectrum between granulomatous rosacea and sarcoidosis [ 6 ]. Treatment with the nm diode laser.

A Review of Lupus Miliaris Disseminatus Faciei-Like Histopathologic Changes in 10 Cases

Multiple monomorphic papules over face Click here to view. Sign in to save your search Sign in to your personal account.

Based on the frequent association with the hair follicle, LMDF has been proposed to represent an immune response to the pilosebaceous units, triggered by hair follicle destruction or ruptured epidermal cysts. June 28, ; Published date: LMDF is an uncommon dermatosis, with about cases reported dissemnatus date.

Clinically, this dermatosis appears as small, discrete, reddish-yellow or yellowish-brown asymptomatic papules involving primarily the central face, typically on and around the eyelids, although there are some reports of extrafacial involvement.

The detection of Propionibacterium acnes signatures in granulomas of lupus miliaris disseminatus faciei.

Lupus miliaris disseminatus faciei pathology

Report of a new case and brief literature review. Andrews’ Diseases of the Skin.


Report of two cases. The upper dermis shows few epithelioid cell granulomas with the presence of giant cells, surrounded by chronic inflammatory cell infiltrate. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account.


Journal List Indian J Dermatol v. Each stage has distinct histological findings.

Br J Dermatol ; Mycobacterial and fungal infections may be ruled out with special stains Ziehl Neelson and GMS respectively. Our patient facei not tolerate tetracycline-class antibiotics, and her disease was resistant to treatment with several systemic agents, including erythromycin, isotretinoin, and prednisone. Fragmented skin biopsy showing mild focal acanthosis with focal follicular plugging.

Miliadis miliaris disseminatus faciei has a spontaneously resolving course, yet can be cosmetically debilitating given the location and potential for scarring.

Therapy is difficult with variable efficacy and several therapeutic modalities, e. Complete resolution of skin lesions was noted by the third treatment.

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